更新内容

可以设置深色模式，不跟随系统设置

下载地址，http://support.weixin.qq.com/cgi-bin/mmsupport-bin/readtemplate?t=page/android_exp__index

复制到微信中打开下载哦！

方法一

报错提示一般是多了个空格，将新加的配置多余空格删除即可。

方法二

若配置文件确实没问题，可能conf文件被记事本编辑过，保存成了含[BOM] 。所以才报错的。

解决办法
使用editplus 等其它非记事本 另存为 UTF-8 不含BOM 的文件就可以了。

The Chinese scientific research team recently published a paper online in the United States "Science" magazine that they found two human monoclonal antibodies that can effectively block the infection of the new coronavirus, which is expected to be used in the development of anti-new crown drugs and vaccines.

Many units including the Capital Medical University of China, the Institute of Microbiology of the Chinese Academy of Sciences, the Tianjin Institute of Industrial Biotechnology of the Chinese Academy of Sciences, and the Third People's Hospital of Shenzhen participated in this study.

The researchers isolated four human monoclonal antibodies from the peripheral blood mononuclear cells of a newly rehabilitated patient.

Experiments show that these four antibodies have the ability to neutralize the new coronavirus. Among them, two antibodies called B38 and H4, respectively, can block the binding of the receptor binding domain of the new crown virus spike protein and its receptor "Angiotensin Converting Enzyme 2 (ACE2)".

A number of previous studies that revealed the infection mechanism of the new coronavirus have shown that the virus mainly achieves infection through the binding of its spike protein receptor binding domain to ACE2 on human cells.

Experiments have shown that B38 and H4 respectively recognize different epitopes of the receptor binding domain. Mouse experiments confirmed that these two antibodies can reduce the amount of virus infecting the lungs of mice, showing a therapeutic effect. The two antibodies can also be used in combination to more effectively suppress viral infections.

The research team further analyzed the structure of the complex formed by the new crown virus spike protein receptor binding region and B38, thus revealing the molecular mechanism of B38 blocking viral infection.

Researcher Introduction

The latest research shows that the two antibodies screened have the potential to be further developed into new coronavirus infection drugs, and provide a basis for vaccine design. At present, the two antibodies have been transformed into products by related companies, and are expected to be used for clinical treatment of patients with new crowns in the future.

nginx在反向代理HTTP协议的时候，默认使用的是HTTP1.0去向后端服务器获取响应的内容后在返回给客户端。
HTTP1.0和HTTP1.1的一个不同之处就是，HTTP1.0不支持HTTP keep-alive。nginx在后端服务器请求时使用了HTTP1.0同时使用HTTP Header的Connection：Close通知后端服务器主动关闭连接。这样会导致任何一个客户端的请求都在后端服务器上产生了一个TIME-WAIT状态的连接。所以我们需要在Nginx上启用HTTP1.1的向后端发送请求，同时支持Keep-alive。

配置方法

我们增加三个参数keepalive 50，proxy_http_version 1.1 , proxy_set_header Connection 来配置。
upstream http_backend {

server 127.0.0.1:8080;
keepalive 50;

}
server {

...
location /http/ {
    proxy_pass http://http_backend;
    proxy_http_version 1.1;
    proxy_set_header Connection "";
    ...
}

}

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